Wear Debris Characterization and Corresponding Biological Response: Artificial Hip and Knee Joints

Nine, Md J. and Choudhury, Dipankar and Hee, Ay Ching and Mootanah, Rajshree and Abu Osman, Noor A. (2014) Wear Debris Characterization and Corresponding Biological Response: Artificial Hip and Knee Joints. Materials, 7 (2). pp. 980-1016. ISSN 1996-1944

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Official URL: http://doi.org/10.3390/ma7020980

Abstract

Wear debris, of deferent sizes, shapes and quantities, generated in artificial hip and knees is largely confined to the bone and joint interface. This debris interacts with periprosthetic tissue and may cause aseptic loosening. The purpose of this review is to summarize and collate findings of the recent demonstrations on debris characterization and their biological response that influences the occurrence in implant migration. A systematic review of peer-reviewed literature is performed, based on inclusion and exclusion criteria addressing mainly debris isolation, characterization, and biologic responses. Results show that debris characterization largely depends on their appropriate and accurate isolation protocol. The particles are found to be non-uniform in size and non-homogeneously distributed into the periprosthetic tissues. In addition, the sizes, shapes, and volumes of the particles are influenced by the types of joints, bearing geometry, material combination, and lubricant. Phagocytosis of wear debris is size dependent; high doses of submicron-sized particles induce significant level of secretion of bone resorbing factors. However, articles on wear debris from engineered surfaces (patterned and coated) are lacking. The findings suggest considering debris morphology as an important parameter to evaluate joint simulator and newly developed implant materials.

Item Type: Journal Article
Keywords: Wear Debris, Isolation, Morphology, Biological Response, Nano-Toxicity
Faculty: Faculty of Science & Technology
Depositing User: Rajshree Hillstrom
Date Deposited: 25 Jan 2017 14:14
Last Modified: 01 Aug 2019 14:52
URI: http://arro.anglia.ac.uk/id/eprint/701391

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