Changes in Frailty Status and Risk of Depression: Results From the Progetto Veneto Anziani Longitudinal Study

De Rui, Marina and Veronese, Nicola and Trevisan, Caterina and Carraro, Sara and Berton, Linda and Maggi, Stefania and Zambon, Sabina and Corti, Maria Chiara and Baggio, Giovannella and Stubbs, Brendon and Perissinotto, Egle and Crepaldi, Gaetano and Manzato, Enzo and Sergi, Giuseppe (2016) Changes in Frailty Status and Risk of Depression: Results From the Progetto Veneto Anziani Longitudinal Study. American Journal of Geriatric Psychiatry.

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Objective To evaluate whether prefrailty was associated with the risk of developing depression and if longitudinal changes in frailty status corresponded to changes in incident depression during follow up. Methods A population-based, prospective cohort study was conducted for 4.4 years in two separate geographic areas near the city of Padua in the Veneto Region of Northern Italy. In 891 nondepressed, nonfrail, community-dwelling Italian subjects aged ≥ 65 (46.6% men) belonging to the Progetto Veneto Anziani study, depression was defined according to the Geriatric Depression Scale and was confirmed by geriatricians skilled in psychogeriatric medicine. Prefrailty was defined by the presence of one or two criteria among the Fried criteria. Results The incidence rate of depression was 13.3% among subjects improving their frailty status at follow-up (N = 15), 15.0% in those who remained stable (N = 79), and 26.7% among worsening participants (N = 67) (p = 0.001). Prefrailty at baseline did not predict the onset of depression (HR: 0.82; 95% CI: 0.55–1.21; Wald χ2 = 0.73; df = 1; p = 0.43), but a deterioration during follow-up in at least one additional frailty criteria was associated with a significantly higher risk (HR: 1.95; 95% CI: 1.32–2.89; Wald χ2 = 5.78; df = 2; p = 0.01). Improvement in frailty status was not associated with the risk of incident depression (HR: 0.71; 95% CI: 0.35–1.42; Wald χ2 = 0.47; df = 2; p = 0.28). Conclusion Our data did not offer evidence that prefrailty per se predisposes to the onset of depression, but worsening in frailty status is associated with an almost twofold increased risk of incident depression, irrespective from the initial level of impairment.

Item Type: Journal Article
Keywords: frailty, depression, elderly, prefrailty, aging
Faculty: Faculty of Health, Social Care & Education (for research post September 2011)
Depositing User: Brendon Stubbs
Date Deposited: 07 Dec 2016 11:41
Last Modified: 04 Apr 2017 13:19

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