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Embedded 3D Printing of Novel Bespoke Soft Dosage Form Concept for Pediatrics

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posted on 2023-07-26, 14:52 authored by Katarzyna Rycerz, Krzysztof A. Stepien, Marta Czapiewska, Basel Arafat, Rober Habashy, Abdullah Isreb, Matthew Peak, Mohamed A. Alhnan
Embedded three-dimensional printing (e-3DP) is an emerging method for additive manufacturing where semi-solid materials are extruded within a solidifying liquid matrix. Here, we present the first example of employing e-3DP in the pharmaceutical field and demonstrate the fabrication of bespoke chewable dosage forms with dual drug loading for potential use in pediatrics. LegoTM-like chewable bricks made of edible soft material (gelatin-based matrix) were produced by directly extruding novel printing patterns of model drug ink (embedded phase) into a liquid gelatin-based matrix (embedding phase) at an elevated temperature (70 °C) to then solidify at room temperature. Dose titration of the two model drugs (paracetamol and ibuprofen) was possible by using specially designed printing patterns of the embedded phase to produce varying doses. A linearity [R2 = 0.9804 (paracetamol) and 0.9976 (ibuprofen)] was achieved between percentage of completion of printing patterns and achieved doses using a multi-step method. The impact of embedded phase rheological behavior, the printing speed and the needle size of the embedded phase were examined. Owning to their appearance, modular nature, ease of personalizing dose and geometry, and tailoring and potential inclusion of various materials, this new dosage form concept holds a substantial promise for novel dosage forms in pediatrics.

History

Refereed

  • Yes

Volume

11

Issue number

12

Page range

630

Publication title

Pharmaceutics

ISSN

1999-4923

Publisher

MDPI

File version

  • Published version

Language

  • eng

Legacy posted date

2020-02-05

Legacy creation date

2020-02-05

Legacy Faculty/School/Department

Faculty of Health, Education, Medicine & Social Care

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