posted on 2023-08-30, 16:35authored byIqbal S. Toor, Dominik Ruckerl, Iris Mair, Rob Ainsworth, Marco Meloni, Ana-Mishel Spiroski, Cecile Benezech, Jennifer M. Felton, Adrian Thomson, Andrea Caporali, Thomas R. Keeble, Kare H. Tang, Adriano G. Rossi, David E. Newby, Judith E. Allen, Gillian A. Gray
In ST-segment elevation myocardial infarction of both patients and mice, there was a decline in blood eosinophil count, with activated eosinophils recruited to the infarct zone. Eosinophil deficiency resulted in attenuated anti-inflammatory macrophage polarization, enhanced myocardial inflammation, increased scar size, and deterioration of myocardial structure and function. Adverse cardiac remodeling in the setting of eosinophil deficiency was prevented by interleukin-4 therapy.