Anglia Ruskin Research Online (ARRO)
Browse

File(s) under permanent embargo

Association between lower limb osteoarthritis and incidence of depressive symptoms: data from the osteoarthritis initiative

journal contribution
posted on 2023-09-01, 14:01 authored by Nicola Veronese, Brendon Stubbs, Marco Solmi, Toby Smith, Marianna Noale, Cyrus Cooper, Stefania Maggi
BACKGROUND: osteoarthritis (OA) is associated with a number of medical morbidities. Although the prevalence of depression and depressive symptoms is presumed to be high in people with OA, no prospective comparative study has analyzed its incidence. OBJECTIVE: to determine whether OA was associated with an increased odds of developing depressive symptoms. DESIGN: longitudinal cohort study (follow-up: 4.2 years). SETTING: data were gathered from the North American Osteoarthritis Initiative (OAI) dataset. SUBJECTS: people at higher risk developing OA. METHODS: OA diagnosis was defined as the presence of OA at hand, knee, hip, back/neck or other sites at baseline. Depressive symptoms were defined using the 20-item Center for Epidemiologic Studies-Depression (cut-off 16 points) after 4 years. RESULTS: a total of 3,491 people without depressive symptoms at baseline were analyzed (1,506 with OA/1,985 without). Using an adjusted logistic regression analysis for 12 potential confounders, people with OA had a similar odds of depressive symptoms at follow-up compared to those without OA (odds ratio (OR): 1.26; 95% confidence of interval (CI): 0.95-1.67). However, multi-site OA (i.e. OA ≥2 sites; OR: 1.48, 95% CI: 1.07-2.05) and the specific presence of hip (OR: 1.72; 95% CI: 1.08-2.73) or knee OA (OR: 1.43; 95% CI: 1.03-1.98) were associated with a greater odds of developing depressive symptoms compared to people without OA. CONCLUSIONS: this is the first study of longitudinal data to demonstrate people with multi-site, hip or knee OA have a greater odds of developing depressive symptoms compared to people without OA. This suggests that OA may be associated with future mental health burden.

History

Refereed

  • Yes

Volume

46

Issue number

3

Page range

470-476

Publication title

Age and Ageing

ISSN

1468-2834

Publisher

Oxford University Press

File version

  • Other

Language

  • eng

Legacy posted date

2016-12-16

Legacy Faculty/School/Department

ARCHIVED Faculty of Health, Social Care & Education (until September 2018)

Usage metrics

    ARU Outputs

    Categories

    No categories selected

    Licence

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC