McCarthy_2016.pdf (408.48 kB)
Childhood-Diagnosed ADHD, Symptom Progression, and Reversal Learning in Adulthood
journal contribution
posted on 2023-08-30, 14:28 authored by Hazel McCarthy, Jessica Stanley, Richard M. Piech, Norbert Skokauskas, Aisling Mulligan, Gary Donohoe, Diane Mullins, John Kelly, Katherine Johnson, Andrew Fagan, Michael Gill, James Meaney, Thomas FrodlObjective: ADHD persists in up to 60% into adulthood, and the reasons for persistence are not fully understood. The objective of this study was to characterize the neurofunctional basis of decision making in those with a childhood diagnosis of ADHD with either persistent or remitted symptoms in adulthood versus healthy control participants. Method: Thirty-two adults diagnosed with ADHD as children were split into persistent (n = 18) or remitted (n = 14) ADHD groups. Their neural activity and neurofunctional connectivity during a probabilistic reversal learning task were compared with 32 healthy controls. Results: Remitters showed significantly higher neural connectivity in final reversal error and probabilistic error conditions, and persisters depict higher neural connectivity in reversal errors than controls at a family-wise error (FWE) corrected whole-brain corrected threshold. Conclusion: Remitters may have utilized higher neural connectivity than controls to make successful decisions. Also, remitters may have utilized compensatory strategies to override any potential underlying ADHD deficits.
History
Refereed
- Yes
Volume
22Issue number
6Page range
561-570Publication title
Journal of Attention DisordersISSN
1557-1246External DOI
Publisher
SAGEFile version
- Accepted version
Language
- eng
Official URL
Legacy posted date
2016-10-25Legacy creation date
2016-10-25Legacy Faculty/School/Department
ARCHIVED Faculty of Science & Technology (until September 2018)Usage metrics
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