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The contribution of zinc to platelet behaviour during haemostasis and thrombosis

journal contribution
posted on 2023-09-01, 13:55 authored by Nicholas Pugh, Kirk A. Taylor
Platelets are the primary cellular determinants of haemostasis and pathological thrombus formation leading to myocardial infarction and stroke. Following vascular injury or atherosclerotic plaque rupture, platelets are recruited to sites of damage and undergo activation induced by a variety of soluble and/or insoluble agonists. Platelet activation is a multi-step process culminating in the formation of thrombi, which contribute to the haemostatic process. Zinc (Zn2+) is acknowledged as an important signalling molecule in a diverse range of cellular systems, however there is limited understanding of the influence of Zn2+ on platelet behaviour during thrombus formation. This review evaluates the contributions of exogenous and intracellular Zn2+ to platelet function and assesses the potential pathophysiological implications of Zn2+ signalling. We also provide a speculative assessment of the mechanisms by which platelets could respond to changes in extracellular and intracellular Zn2+ concentration.

History

Refereed

  • Yes

Volume

8

Page range

144-155

Publication title

Metallomics

ISSN

1756-591X

Publisher

Royal Society of Chemistry

File version

  • Accepted version

Language

  • eng

Legacy posted date

2016-02-02

Legacy creation date

2020-02-20

Legacy Faculty/School/Department

ARCHIVED Faculty of Science & Technology (until September 2018)

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