Hegedus_et_al_2014.pdf (449.02 kB)
Protection Versus Pathology in Aviremic and High Viral Load HIV-2 Infection—The Pivotal Role of Immune Activation and T-cell Kinetics
journal contribution
posted on 2023-07-26, 13:41 authored by Andrea Hegedus, Samuel Nyamweya, Yan Zhang, Sheila Govind, Richard Aspinall, Alla Mashanova, Vincent A. A. Jansen, Hilton Whittle, Assan Jaye, Katie L. Flanagan, Derek C. MacallanBACKGROUND:
Many human immunodeficiency virus (HIV)-2-infected individuals remain aviremic and behave as long-term non-progressors but some progress to AIDS. We hypothesized that immune activation and T-cell turnover would be critical determinants of non-progressor/progressor status.
METHODS:
We studied 37 subjects in The Gambia, West Africa: 10 HIV-negative controls, 10 HIV-2-infected subjects with low viral loads (HIV-2-LV), 7 HIV-2-infected subjects with high viral loads (HIV-2-HV), and 10 with HIV-1 infection. We measured in vivo T-cell turnover using deuterium-glucose labeling, and correlated results with T-cell phenotype (by flow cytometry) and T-cell receptor excision circle (TREC) abundance.
RESULTS:
Immune activation (HLA-DR/CD38 coexpression) differed between groups with a significant trend: controls
History
Refereed
- Yes
Volume
210Issue number
5Page range
752-761Publication title
Journal of Infectious DiseasesISSN
1537-6613External DOI
Publisher
Oxford University PressFile version
- Published version
Language
- eng
Official URL
Legacy posted date
2015-12-07Legacy creation date
2022-02-23Legacy Faculty/School/Department
ARCHIVED Faculty of Medical Science (until September 2018)Usage metrics
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