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Proximal protection with the Gore PAES can reduce DWI lesion size in high-grade stenosis during carotid stenting
journal contribution
posted on 2023-07-26, 13:40 authored by Iris Q. Grunwald, Wolfgang Reith, Anna L. Kühn, Joyce S. Balami, Kerstin Karp, Klaus Fassbender, Silke Walter, Panagiotis Papanagiotou, Christoph KrickAIMS: The aim was to determine the incidence of new ischaemic lesions on diffusion-weighted MR imaging (DWI) in a non-randomised cohort of patients after protected and unprotected carotid artery stent placement using the Parodi Anti-Emboli System (PAES).
METHODS AND RESULTS: A retrospective review was conducted on 269 patients who received DWI prior to, and 24-72 hours after, stent placement. All patients were enrolled in one centre. Forty patients stented with the PAES device were matched with 229 patients stented without protection (control group). New diffusion restriction on DWI was detected in 25.8% (PAES) versus 32.3% (control group); p=0.64. On average there were 0.7 lesions (PAES) versus 0.8 lesions (control group) per patient. The area of lesions was 1.7 (PAES) versus 5.6 mm2. In a subanalysis of patients (32 PAES, 148 non-protected) with >80% stenosis, the area of restricted diffusion was less when proximal protection was used (p<0.05). The number and area of DWI lesions did not differ on the contralateral, non-stented side. When the PAES system was used, patients were more likely not to have any lesion at all (p=0.028).
CONCLUSIONS: In high-grade stenosis, the use of the Gore PAES device significantly reduced the area of new DWI lesions and patients were more likely not to have any new DWI lesion at all.
History
Refereed
- Yes
Volume
10Issue number
2Page range
271-276Publication title
EuroInterventionISSN
1969-6213External DOI
Publisher
Europa GroupLanguage
- other
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Legacy posted date
2015-10-22Legacy Faculty/School/Department
ARCHIVED Faculty of Medical Science (until September 2018)Usage metrics
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