IOVS-14-15385-Diurnal IOP SS OCT Anterior Chamber Dimensions -FINAL-27 3 15.pdf (135.89 kB)
Diurnal Intraocular Pressure and the Relationship With Swept-Source OCT–Derived Anterior Chamber Dimensions in Angle Closure: The IMPACT Study
journal contribution
posted on 2023-08-30, 14:09 authored by Laura Sanchez-Parra, Shahina Pardhan, Roger J. Buckley, Michael Parker, Rupert R. A. BournePurpose:
To evaluate diurnal intraocular pressure (DIOP) among individuals with Primary Angle Closure (PAC) or Primary Angle Closure Suspect (PACS). Additionally the hypothesis that greater DIOP fluctuation is related to smaller angle parameters was investigated.
Methods:
40 Caucasian newly referred untreated patients with bilateral PAC or PACS were recruited. Intraocular pressure (IOP) was measured hourly between 09.00 and 16.00 with Goldmann applanation tonometry. DIOP fluctuation was defined as difference between maximum and minimum IOP. Angle Opening Distance, AOD; Trabecular-Iris Angle (TIA); Angle Recess Area (ARA); Trabecular Iris Space Area (TISA) were measured with AS-OCT (CASIA) in dark (0.3-0.5 lux) and light (170-200 lux) on the same day as DIOP measurements in eight angle sections.
Results:
IOP declined as the day progressed (p<0.001), unrelated to presence of PAS. At each timepoint, eyes with PAS (n=31) had significantly higher IOPs than eyes without PAS (n=49; p=0.043). DIOP fluctuation varied from 1.50 mmHg to 14.50 mmHg (mean 5.99 mmHg, SD 2.70 mmHg). DIOP fluctuation was unrelated to PAS. Multiple-predictor models investigating association of angle dimensions and greater DIOP fluctuation were statistically significant for AOD 750 (light), ARA 750 (light and dark), TISA 500 (light), TISA 750 (light), TIA 500 (light) and TIA 750 (light and dark).
Conclusions:
DIOP variation has clinical implications given that IOP level is used to distinguish between diagnostic categories of PACS and PAC. OCT angle parameter measurements may predict for magnitude of IOP diurnal fluctuations in at-risk patients, which may be clinical useful when considering a clinical intervention.
History
Refereed
- Yes
Volume
56Issue number
5Page range
2943-2949Publication title
Investigative Ophthalmology & Visual ScienceISSN
1552-5783External DOI
Publisher
ARVOFile version
- Accepted version
Language
- eng
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Legacy posted date
2015-09-11Legacy creation date
2017-10-16Legacy Faculty/School/Department
ARCHIVED Faculty of Medical Science (until September 2018)Usage metrics
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