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Decreased poly(ADP-ribosyl)ation of CTCF, a transcription factor, is associated with breast cancer phenotype and cell proliferation

journal contribution
posted on 2023-07-26, 12:49 authored by France Docquier, Georgia-Xanthi Kita, Dawn Farrar, Parmjit Jat, Michael O'Hare, Igor Chernukhin, Svetlana Gretton, Adhip Mandal, Louise Alldridge, Elena Klenova
There is compelling evidence of a relationship between poly(ADP-ribosyl)ation and tumorigenesis; however, much less is known about the role of specific targets of poly(ADP-ribosyl)ation in tumor development. Two forms of the multifunctional transcription factor, CTCF, were previously identified: a 130-kDa protein (CTCF-130), characteristic for cell lines, and a 180-kDa protein (CTCF-180), modified by poly(ADP-ribosyl)ation. This study was aimed to investigate differential poly(ADP-ribosyl)ation of CTCF in normal and tumor breast tissues.

History

Refereed

  • Yes

Volume

15

Issue number

18

Page range

5762-5771

Publication title

Clinical Cancer Research

ISSN

1557-3265

Publisher

American Association for Cancer Research

Language

  • other

Legacy posted date

2011-09-20

Legacy Faculty/School/Department

ARCHIVED Faculty of Health, Social Care & Education (until September 2018)

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