Development of a harmonised method for the profiling of amphetamines: IV. Optimisation of sample preparation

Andersson, Kjell and Jalava, Kaisa and Lock, Eric and Huizer, Henk and Kaa, Elisabet and Lopes, Alvaro and Poortman-van der Meer, Anneke and Cole, Michael D. and Dahlén, Johan and Sippola, Erkki (2007) Development of a harmonised method for the profiling of amphetamines: IV. Optimisation of sample preparation. Forensic Science International. ISSN 0379-0738

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Abstract

The suitability of liquid–liquid extraction (LLE) and solid-phase extraction (SPE) for the preparation of impurity extracts intended for gas chromatographic profiling analyses of amphetamine were evaluated. Both techniques were optimised with respect to the extraction of selected target compounds by use of full factorial designs in which the variables affecting the performance were evaluated. Test samples consisted of amphetamine synthesised by the Leuckart reaction, by reductive amination of benzyl methyl ketone and by the nitrostyrene route. The performance of LLE and SPE were comparable in terms of repeatability and recovery of the target compounds. LLE was considered the better choice for the present harmonised amphetamine profiling method due to the lack of information on the long-term stability of SPE columns.

Item Type: Journal Article
Additional Information: Citation: Andersson, K., Cole, M.D. et al., 2007. Development of a harmonised method for the profiling of amphetamines: IV. Optimisation of sample preparation. Forensic Science International, 169(1), pp.64-76..
Faculty: Faculty of Science & Technology
Depositing User: Mr I Walker
Date Deposited: 05 May 2010 15:57
Last Modified: 30 Jun 2017 11:36
URI: http://arro.anglia.ac.uk/id/eprint/97992

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