Depression in Cancer: the many biobehavioural pathways driving tumor progression

Bortolato, Beatrice and Hyphantis, Thomas N. and Valpione, Sara and Perini, Giulia and Maes, Michael and Morris, Gerwyn and Marta Kubera, Marta and Köhler, Cristiano A. and Fernandes, Brisa S. and Stubbs, Brendon and Pavlidis, Nicholas and Carvalho, Andre F. (2016) Depression in Cancer: the many biobehavioural pathways driving tumor progression. Cancer Treatment Reviews. ISSN 0305-7372

[img]
Preview
Text
Accepted Version
Available under the following license: Creative Commons Attribution Non-commercial No Derivatives.

Download (811kB) | Preview
[img] Other (Acceptance email)
Other
Restricted to Repository staff only

Download (184kB)
Official URL: http://dx.doi.org/10.1016/j.ctrv.2016.11.004

Abstract

Major Depressive Disorder (MDD) is common among cancer patients, with prevalence rates up to four-times higher than the general population. Depression confers worse outcomes, including non-adherence to treatment and increased mortality in the oncology setting. Advances in the understanding of neurobiological underpinnings of depression have revealed shared biobehavioral mechanisms may contribute to cancer progression. Moreover, psychosocial stressors in cancer promote: (1) inflammation and oxidative/nitrosative stress; (2) a decreased immunosurveillance; and (3) a dysfunctional activation of the autonomic nervous system and of the hypothalamic-pituitary-adrenal axis. Consequently, the prompt recognition of depression among patients with cancer who may benefit of treatment strategies targeting depressive symptoms, cognitive dysfunction, fatigue and sleep disturbances, is a public health priority. Moreover, behavioral strategies aiming at reducing psychological distress and depressive symptoms, including addressing unhealthy diet and life-style choices, as well as physical inactivity and sleep dysfunction, may represent important strategies not only to treat depression, but also to improve wider cancer-related outcomes. Herein, we provide a comprehensive review of the intertwined biobehavioural pathways linking depression to cancer progression. In addition, the clinical implications of these findings are critically reviewed.

Item Type: Journal Article
Keywords: major depressive disorder, cancer, inflammation, HPA axis, stress, psychiatry
Faculty: Faculty of Health, Social Care & Education (for research post September 2011)
Depositing User: Brendon Stubbs
Date Deposited: 23 Nov 2016 11:11
Last Modified: 16 Nov 2017 02:02
URI: http://arro.anglia.ac.uk/id/eprint/701151

Actions (login required)

Edit Item Edit Item