Inflammation and sarcopenia: A systematic review and meta-analysis

Bano, Giulia and Trevisana, Caterina and Carraroa, Sara and Solmibi, Marco and Luchinici, Claudio and Stubbs, Brendon and Manzato, Enzo and Sergi, Giuseppe and Veronesea, Nicola (2016) Inflammation and sarcopenia: A systematic review and meta-analysis. Maturitas. ISSN 0378-5122

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nflammatory cytokines have been shown to prompt muscle wasting, ultimately stimulating protein catabolism and suppressing muscle synthesis. However, the possible association between inflammatory parameters and sarcopenia is poorly understood. We therefore aimed to summarize the current evidence about this topic with a meta-analysis of studies reporting serum inflammatory parameters in patients with sarcopenia vs. people without sarcopenia (controls). An electronic PubMed and Scopus search through to 09/01/2016 and meta-analysis of cross-sectional studies comparing serum levels of inflammatory cytokines between patients with sarcopenia and controls was made, calculating random-effects standardized mean differences (SMDs) ±95% confidence intervals (CIs) as the effect size. Out of 1370 initial hits, 17 studies with a total of 11249 participants (3072 with sarcopenia and 8177 without) were meta-analyzed. Sarcopenic participants had significantly higher levels of CRP (SMD = 0.51; 95%CI 0.26, 0.77; p < 0.0001; I2 = 96%) than controls. Conversely, serum IL6 levels were not significantly different (SMD = 0.35; 95%CI: −0.19, 0.89; p = 0.21; I2 = 97%) in people with sarcopenia versus controls. Sarcopenic people did not have higher levels of TNF-α than controls (SMD = 0.28; 95%CI −0.26, 0.83; p = 0.31; I2 = 97%). In conclusion, sarcopenia seems to be associated with elevated serum CRP levels; future longitudinal studies are needed to clarify this relationship.

Item Type: Journal Article
Keywords: inflammation, sarcopenia
Faculty: Faculty of Health, Social Care & Education (for research post September 2011)
Depositing User: Unnamed user with email
Date Deposited: 23 Nov 2016 10:08
Last Modified: 04 Apr 2017 09:04

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