A facile approach to manufacturing non-ionic surfactant nanodipsersions using proniosome technology and high-pressure homogenization

Najlah, Mohammad and Hidayat, Kanar and Omer, Huner K. and Mwesigwa, Enosh and Ahmed, Waqar and AlObaidy, Kais G. and Phoenix, David A. and Elhissi, Abdelbary (2014) A facile approach to manufacturing non-ionic surfactant nanodipsersions using proniosome technology and high-pressure homogenization. Journal of Liposome Research, 25 (1). pp. 32-37. ISSN 0898-2104

Full text not available from this repository.
Official URL: http://doi.org/10.3109/08982104.2014.924140

Abstract

n this study, a niosome nanodispersion was manufactured using high-pressure homogeniza- tion following the hydration of proniosomes. Using beclometasone dipropionate (BDP) as a model drug, the characteristics of the homogenized niosomes were compared with vesicles prepared via the conventional approach of probe-sonication. Particle size, zeta potential, and the drug entrapment efficiency were similar for both size reduction mechanisms. However, high-pressure homogenization was much more efficient than sonication in terms of homogenization output rate, avoidance of sample contamination, offering a greater potential for a large-scale manufacturing of noisome nanodispersions. For example, high-pressure homogenization was capable of producing small size niosomes (209 nm) using a short single- step of size reduction (6 min) as compared with the time-consuming process of sonication (237 nm in 4 18 min) and the BDP entrapment efficiency was 29.65% ± 4.04 and 36.4% ± 2.8. In addition, for homogenization, the output rate of the high-pressure homogenization was 10 ml/min compared with 0.83 ml/min using the sonication protocol. In conclusion, a facile, applicable, and highly efficient approach for preparing niosome nanodispersions has been established using proniosome technology and high-pressure homogenization.

Item Type: Journal Article
Keywords: Homogenization, niosome, size
Depositing User: Dr Mohammad Najlah
Date Deposited: 14 Nov 2016 11:07
Last Modified: 14 Nov 2016 11:07
URI: http://arro.anglia.ac.uk/id/eprint/701127

Actions (login required)

Edit Item Edit Item