Efficient approach to enhance drug solubility by particle engineering of bovine serum albumin

Khoder, Mouhamad and Abdelkader, Hamdy and ElShaer, Amr and Karam, Ayman and Najlah, Mohammad and Alany, Raid G. (2016) Efficient approach to enhance drug solubility by particle engineering of bovine serum albumin. International Journal of Pharmaceutics, 515 (1-2). pp. 740-748. ISSN 03785173 (Accepted)

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Official URL: http://doi.org/10.1016/j.ijpharm.2016.11.019

Abstract

The aim of this study was to investigate the use of bovine serum albumin (BSA) as a solubility enhancer for indometacin (IND) as a model drug. IND-BSA solid dispersions were prepared by both spray drying and freeze drying techniques using IND:BSA solution (20:1 Molar Ratio (MR)) and IND:BSA suspension (100:1 MR). The solid state of IND in solid dispersions was characterised by SEM, DSC and XRD. The aqueous solubility of IND in the presence of increased amounts of BSA was evaluated. Additionally, IND dissolution and release profiles were evaluated. IND in solid dispersions with BSA showed significantly higher solubility in water than that of the physical mixture of both. Enhancement factors of 24,000 and 100,000 were obtained for the solid dispersion formulated in 20:1 MR and 100:1 MR, respectively. Dissolution studies in-vitro indicated a significant increase in the dissolution rate of IND from solid dispersions compared to that of the free drug, with almost 95% of the drug dissolved in the first 5 min. Furthermore, an immediate release of IND from BSA solid dispersions was shown. The potential use of albumin as solubility enhancer for poorly soluble drugs, particularly, for immediate release volume-limited dosage forms is reported.

Item Type: Journal Article
Keywords: Bovine serum albumin;, Indometacin;, Solid dispersion;, Solubility enhancer;
Depositing User: Dr Mohammad Najlah
Date Deposited: 14 Nov 2016 11:26
Last Modified: 07 Nov 2017 02:02
URI: http://arro.anglia.ac.uk/id/eprint/701124

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