Protease stimulation of renal sodium reabsorption in vivo by activation of the collecting duct epithelial sodium channel (ENaC).

Jacquillet, Grégory and Chichger, Havovi and Unwin, Robert J and Shirley, David G (2013) Protease stimulation of renal sodium reabsorption in vivo by activation of the collecting duct epithelial sodium channel (ENaC). Nephrology Dialysis Transplantation. ISSN 1460-2385 (Draft)

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Abstract

Proteases can increase the activity of the epithelial sodium channel (ENaC) by cleaving its α- or γ-subunit. However, evidence so far comes only from studies in vitro in either heterologous expression systems or isolated nephron segments. The present study has tested whether exposure to a luminal protease can alter sodium reabsorption along the rat collecting duct in vivo.

Item Type: Journal Article
Additional Information: Citation: Jacquillet, G., Chichger, H., Unwin, R. J., & Shirley, D. G. (2013). Protease stimulation of renal sodium reabsorption in vivo by activation of the collecting duct epithelial sodium channel (ENaC). Nephrology Dialysis Transplantation, 28(4), 839-845.
Faculty: Faculty of Science & Technology
Depositing User: Mr I Walker
Date Deposited: 01 Jun 2016 08:38
Last Modified: 07 Jul 2016 12:54
URI: http://arro.anglia.ac.uk/id/eprint/611359

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