Modified platelet deposition on matrix metalloproteinase 13 digested collagen I

Howes, Joanna-Marie and Pugh, Nicholas and Knäuper, Vera and Farndale, Richard W. (2015) Modified platelet deposition on matrix metalloproteinase 13 digested collagen I. Journal of Thrombosis and Haemostasis. ISSN 1538-7836

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Abstract

Atherothrombosis underlies acute coronary syndromes, including unstable angina and acute myocardial infarction. Within the unstable plaque, monocytes express collagenolytic matrix metalloproteinases (MMPs) including MMP-13 which degrades fibrous collagen. Following rupture, vessel wall components including degraded collagen are exposed to circulating platelets. Platelet receptors then mediate the recruitment and activation of platelets to form a thrombus, blocking blood flow and resulting in myocardial infarction and sudden death.

Item Type: Journal Article
Additional Information: Citation: Howes, J., Pugh, N., Knäuper, V. and Farndale, R. W. 2015. Modified platelet deposition on MMP-13 digested collagen I. Journal of Thrombosis and Haemostasis. 13(12), pp. 2253–9..
Faculty: Faculty of Science & Technology
Depositing User: Mr I Walker
Date Deposited: 23 Dec 2015 10:50
Last Modified: 07 Jul 2016 12:54
URI: http://arro.anglia.ac.uk/id/eprint/592532

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