Protection versus pathology in aviremic and high viral load HIV-2 infection-the pivotal role of immune activation and T-cell kinetics.

Hegedus, Andrea and Nyamweya, Samuel and Zhang, Yan and Govind, Sheila and Aspinall, Richard and Mashanova, Alla and Jansen, Vincent A. A. and Whittle, Hilton and Jaye, Assan and Flanagan, Katie L. and Macallan, Derek C. (2014) Protection versus pathology in aviremic and high viral load HIV-2 infection-the pivotal role of immune activation and T-cell kinetics. The Journal of Infectious Diseases. ISSN 1537-6613

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Abstract

BACKGROUND: Many human immunodeficiency virus (HIV)-2-infected individuals remain aviremic and behave as long-term non-progressors but some progress to AIDS. We hypothesized that immune activation and T-cell turnover would be critical determinants of non-progressor/progressor status. METHODS: We studied 37 subjects in The Gambia, West Africa: 10 HIV-negative controls, 10 HIV-2-infected subjects with low viral loads (HIV-2-LV), 7 HIV-2-infected subjects with high viral loads (HIV-2-HV), and 10 with HIV-1 infection. We measured in vivo T-cell turnover using deuterium-glucose labeling, and correlated results with T-cell phenotype (by flow cytometry) and T-cell receptor excision circle (TREC) abundance. RESULTS: Immune activation (HLA-DR/CD38 coexpression) differed between groups with a significant trend: controls <HIV-2-LV <HIV-1 <HIV-2-HV (P < .01 for all cell types). A similar trend was observed in the pattern of in vivo turnover of memory CD4(+) and CD8(+) T-cells and TREC depletion in naive CD4(+) T-cells, although naive T-cell turnover was relatively unaffected by either infection. T-cell turnover, immune activation, and progressor status were closely associated. CONCLUSIONS: HIV-2 non-progressors have low rates of T-cell turnover (both CD4(+) and CD8(+)) and minimal immune activation; high viral load HIV-2 progressors had high values, similar to or exceeding those in HIV-1 infection.

Item Type: Journal Article
Additional Information: Citation: Hegedus, A., Nyamweya, S., Zhang, Y., Govind S., Aspinall, R., Mashanova, A., Jansen, V.A., Whittle, H., Jaye, A., Flanagan, K.L., Macallan, D.C., 2014. Protection versus pathology in aviremic and high viral load HIV-2 infection-the pivotal role of immune activation and T-cell kinetics. The Journal of Infectious Diseases, 210(5), pp. 752-761..
Faculty: Faculty of Medical Science
Depositing User: Mr I Walker
Date Deposited: 07 Dec 2015 11:45
Last Modified: 30 Jun 2017 12:52
URI: http://arro.anglia.ac.uk/id/eprint/583302

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