Dissemination of multiple carbapenem-resistant clones of Acinetobacter baumannii in the Eastern District of Saudi Arabia

Al-Sultan, Abdulrahman A. and Evans, Benjamin A. and Aboulmagd, Elsayed and Al-Qahtani, Ahmed A. and Bohol, Marie Fe F. and Al-Ahdal, Mohammed N. and Opazo, Andres F. and Amyes, Sebastian G. B. (2015) Dissemination of multiple carbapenem-resistant clones of Acinetobacter baumannii in the Eastern District of Saudi Arabia. Frontiers in Microbiology. ISSN 1664-302X

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Abstract

It has previously been shown that carbapenem-resistant Acinetobacter baumannii are frequently detected in Saudi Arabia. The present study aimed to identify the epidemiology and distribution of antibiotic resistance determinants in these bacteria. A total of 83 A. baumannii isolates were typed by pulsed-field gel electrophoresis (PFGE), and screened by PCR for carbapenemase genes and insertion sequences. Antibiotic sensitivity to imipenem, meropenem, tigecycline, and colistin were determined. Eight different PFGE groups were identified, and were spread across multiple hospitals. Many of the PFGE groups contained isolates belonging to World-wide clone 2. Carbapenem resistance or intermediate resistance was detected in 69% of isolates. The blaVIM gene was detected in 94% of isolates, while blaOXA–23–like genes were detected in 58%. The data demonstrate the co-existence and wide distribution of a number of clones of carbapenem-resistant A. baumannii carrying multiple carbapenem-resistance determinants within hospitals in the Eastern Region of Saudi Arabia.

Item Type: Journal Article
Additional Information: Citation: Al-Sultan, A. A., Evans, B. A., Aboulmagd, E., Al-Qahtani, A. A., Bohol, M. F. F., Al-Ahdal, M. N., Opazo, A. F. and Amyes, S. G. B. 2015. Dissemination of multiple carbapenem-resistant clones of Acinetobacter baumannii in the Eastern District of Saudi Arabia. Frontiers in Microbiology, 6(634)..
Faculty: Faculty of Science & Technology
Depositing User: Mr I Walker
Date Deposited: 14 Oct 2015 13:08
Last Modified: 24 Oct 2016 09:01
URI: http://arro.anglia.ac.uk/id/eprint/579634

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