Effects of handgrip exercise or inorganic nitrate supplementation on 24-h ambulatory blood pressure and peripheral arterial function in overweight and obese middle age and older adults: A pilot RCT.

Lara, Jose and Ogbonmwan, Ikponmwonsa and Oggioni, Clio and Zheng, Dingchang and Qadir, Othman and Ashor, Ammar and Brandt, Kirsten and Mathers, John C and Siervo, Mario (2015) Effects of handgrip exercise or inorganic nitrate supplementation on 24-h ambulatory blood pressure and peripheral arterial function in overweight and obese middle age and older adults: A pilot RCT. Maturitas. ISSN 0378-5122

Full text not available from this repository.

Abstract

Introduction Hypertension is a major contributor to the global burden of cardiovascular diseases and its prevalence increases progressively with ageing. Therefore the identification of effective, age-friendly exercise and nutritional interventions which lower blood pressure (BP) is a research priority. Objective To undertake a pilot RCT examining the efficacy of isometric handgrip exercise (IHGE) and beetroot juice (a rich source of inorganic nitrate) consumption in modifying clinic and 24-h ambulatory BP (24-h ABP), peripheral arterial function and plasma asymmetric dimethylarginine (ADMA) in older overweight and obese adults. Design Thirty middle age and older adults (62 ± 5 years) were randomised to: (a) bilateral IHGE at 50% of maximal voluntary contraction (8 min/day), (b) 140 ml/day of concentrated beetroot juice, or (c) no-intervention (control group), for 7 days. All groups followed a standardised diet to control nitrate intake. Clinic and 24-h ABP, peripheral arterial function quantified by pulse wave velocity (PWV) and arterial volume distensibility were assessed before and after intervention. Setting Clinical ageing research unit, Newcastle University. Results At baseline, there were no between-group differences in age, handgrip strength, clinic or 24-h ABP, BMI, waist circumference, fat mass, physical activity level, energy intake or urinary and plasma nitrate concentrations. After intervention, there were no significant effects on clinic systolic and diastolic BP or 24-h ABP, PWV (p = 0.54), arterial volume distensibility (p = 0.89), or ADMA (p = 0.45). Conclusions IHGE or beetroot juice consumption for 7 days did not affect BP or peripheral arterial function in overweight and obese middle age and older adults. Ageing may reduce the effects of these interventions on vascular function and studies are needed to test this hypothesis. Keywords Nitrates; Beetroot juice; Handgrip exercise; Blood pressure

Item Type: Journal Article
Additional Information: Citation: Lara, J., Ogbonmwana, I., Oggionia, C., Zheng, D., Qadira, O., Ashora, A., Brandt, K., Mathers, J. C. and Siervo, M. 2015. Effects of handgrip exercise or inorganic nitrate supplementation on 24-h ambulatory blood pressure and peripheral arterial function in overweight and obese middle age and older adults: A pilot RCT. Maturitas, 82(2), pp. 228-235..
Faculty: Faculty of Medical Science
Depositing User: Mr I Walker
Date Deposited: 13 Oct 2015 15:14
Last Modified: 07 Jul 2016 12:53
URI: http://arro.anglia.ac.uk/id/eprint/579604

Actions (login required)

Edit Item Edit Item