Setting Up an Efficient Therapeutic Hypothermia Team in Conscious ST Elevation Myocardial Infarction Patients: A UK Heart Attack Center Experience

Islam, Shahed and Hampton-Till, James and MohdNazri, Shah and Watson, Noel and Gudde, Ellie and Gudde, Tom and Kelly, Paul A. and Tang, Kare H. and Davies, John R. and Keeble, Thomas R. (2015) Setting Up an Efficient Therapeutic Hypothermia Team in Conscious ST Elevation Myocardial Infarction Patients: A UK Heart Attack Center Experience. Therapeutic Hypothermia and Temperature Management, 5 (4). pp. 217-222. ISSN 2153-7933

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Official URL: http://dx.doi.org/10.1089/ther.2015.0012

Abstract

Patients presenting with ST elevation myocardial infarction (STEMI) are routinely treated with percutaneous coronary intervention to restore blood flow in the occluded artery to reduce infarct size (IS). However, there is evidence to suggest that the restoration of blood flow can cause further damage to the myocardium through reperfusion injury (RI). Recent research in this area has focused on minimizing damage to the myocardium caused by RI. Therapeutic hypothermia (TH) has been shown to be beneficial in animal models of coronary artery occlusion in reducing IS caused by RI if instituted early in an ischemic myocardium. Data in humans are less convincing to date, although exploratory analyses suggest that there is significant clinical benefit in reducing IS if TH can be administered at the earliest recognition of ischemia in anterior myocardial infarction. The Essex Cardiothoracic Centre is the first UK center to have participated in administering TH in conscious patients presenting with STEMI as part of the COOL-AMI case series study. In this article, we outline our experience of efficiently integrating conscious TH into our primary percutaneous intervention program to achieve 18 minutes of cooling duration before reperfusion, with no significant increase in door-to-balloon times, in the setting of the clinical trial.

Item Type: Journal Article
Keywords: therapeutic hypothermia
Faculty: Faculty of Medical Science
Depositing User: Repository Admin
Date Deposited: 11 Sep 2015 10:21
Last Modified: 06 Nov 2017 16:08
URI: http://arro.anglia.ac.uk/id/eprint/577171

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