Acute burn induced coagulopathy

Parker, Michael and Sherren, P.B. and Hussey, J. and Martin, R. and Kundishora, T. and Emerson, B. (2013) Acute burn induced coagulopathy. Burns. ISSN 0305-4179

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Abstract

Background Acute traumatic coagulopathy is well described in the trauma population. Major burns are characterised by a similar endothelial injury and cellular hypoperfusion. These features could be a driver for an acute burn induced coagulopathy (ABIC). Methods Patients admitted to a regional burn centre over a 71 months period with a total body surface area burn of 30% or more were identified. The metavision electronic patient database was scrutinised for a predetermined list of demographics, interventions and admission investigations to identify any clinically significant ABIC. Results On admission 39.3% of the 117 patients analysed met our criteria for a coagulopathy. Of the patients with a coagulopathy, 71.7% had an elevated Prothrombin Time (PT), 2.2% had an elevated Activated Partial Thromboplastin time (APPT) and 26.1% had an elevation of both. Patients with a coagulopathy received a similar volume of fluid (p = 0.08). There was a statistically significant correlation between the PT and the abbreviated burn severity index (p = 0.0013, r = 0.292) and serum lactate (p = 0.0013, r = 0.292). ABIC was an independent predictor of 28 day mortality, OR 3.42(1.11–10.56). Conclusion In patients with major thermal injuries a clinically significant ABIC exists. Early diagnosis and treatment of ABIC should be considered particularly in those undergoing total burn wound excision.

Item Type: Journal Article
Additional Information: Citation: Sherren, P.B., Hussey, J., Martin, R., Kundishora, T., Parker, M. and Emerson, B., 2013. Acute burn induced coagulopathy. Burns, 39(6), pp.1157-1161..
Faculty: Faculty of Health, Social Care & Education (for research post September 2011)
Depositing User: Mr I Walker
Date Deposited: 29 Nov 2013 13:20
Last Modified: 03 Jul 2017 09:06
URI: http://arro.anglia.ac.uk/id/eprint/305933

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