Decreased poly(ADP-ribosyl)ation of CTCF, a transcription factor, is associated with breast cancer phenotype and cell proliferation

Docquier, France and Kita, Georgia-Xanthi and Farrar, Dawn and Jat, Parmjit and O'Hare, Michael and Chernukhin, Igor and Gretton, Svetlana and Mandal, Adhip and Alldridge, Louise and Klenova, Elena (2009) Decreased poly(ADP-ribosyl)ation of CTCF, a transcription factor, is associated with breast cancer phenotype and cell proliferation. Clinical cancer research : an official journal of the American Association for Cancer Research. ISSN 1078-0432

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Abstract

There is compelling evidence of a relationship between poly(ADP-ribosyl)ation and tumorigenesis; however, much less is known about the role of specific targets of poly(ADP-ribosyl)ation in tumor development. Two forms of the multifunctional transcription factor, CTCF, were previously identified: a 130-kDa protein (CTCF-130), characteristic for cell lines, and a 180-kDa protein (CTCF-180), modified by poly(ADP-ribosyl)ation. This study was aimed to investigate differential poly(ADP-ribosyl)ation of CTCF in normal and tumor breast tissues.

Item Type: Journal Article
Additional Information: Citation: Docquier, F., et al., 2009. Decreased poly(ADP-ribosyl)ation of CTCF, a transcription factor, is associated with breast cancer phenotype and cell proliferation. Critical Cancer Research, 15(18), pp.5762-5771..
Faculty: Faculty of Health and Social Care (for research published prior to September 2011)
Depositing User: Mr I Walker
Date Deposited: 20 Sep 2011 11:49
Last Modified: 30 Jun 2017 09:22
URI: http://arro.anglia.ac.uk/id/eprint/142723

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